University of Minnesota Children’s Hospital, Fairview Position(s)
Orthopaedic Surgeon

Other Related Positions Currently Held
Professor, Department of Orthopaedic Surgery, University of Minnesota

Head, Department of Orthopaedic Surgery

Board Certification
Orthopaedic Surgery

Sees Patients At
- University of Minnesota Children's Hospital, Fairview
- Orthopedic Clinic (Minneapolis)
- Oncology Orthopedic Clinic (Minneapolis)

Clinical Interests
Baker Cyst
Orthopaedic Oncology
Pediatric Orthopaedics
Tumors
Musculoskeletal oncology with focus on both primary and metastatic cancers of bone
Management of musculoskeletal problems in hemophilia

Education
Medical School
Northwestern University Medical School

Site of Residency
University of Minnesota

Site of Fellowship
Post-doctoral Research Fellow, Washington University Medical Center, St. Louis, Missouri, Department of Pathology

Harvard Medical School, Department of Orthopaedic Surgery, Massachusetts General Hospital (Musculoskeletal Oncology)

Awards and Honors
Best Doctors in America®, 2007-2008

Research Interest(s)
The effect of surgical treatment of skeletal metastasis on health status

Basic research in cell biology of bone

Selected Recent Publications
Peer Review Publications
Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain 99(3) 397-406, 2002.

Mach DB, Robers SD, Sabino MAC, Luger NM, Schwei MJ, Pomonis JK, Clohisy DR, Adams DJ, O'Leary P, Mantyh PW. Sensory and sympathetic innervation of a normal mouse femur. Neuroscience, 113(1): 155 - 66, 2002.

Thompson RC, Cheng EY, Clohisy DR, Perentesis J, Manivel C, Le CT: Results of treatment for metastatic osteosarcoma in neoadjuvant chemotherapy and surgery. Clinical Orth, 397: 240-247, 2002.

Nagarajan R, Neglia J, Clohisy DR, Robison LL: Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications? J Clin Oncol, 20(22) 4493-4501, 2002.

Mantyh PW, Clohisy DR, Koltzenburg M, Hunt SP: Molecular mechanisms of cancer pain. Nature Reviews: Cancer, (2)201-209, March 2002.

Clohisy DR, Mantyh PW: Bone cancer pain. Cancer 97(3 Suppl), 866-873, 2003.

Clohisy DR: Cellular mechanisms of osteolysis. J Bone Joint Surg Am, 85-A Suppl 1: S4-6, 2003. 

Mohla S, Weilbacher KN, Cher ML, Oyajobi BO, Poznak CV, and Clohisy DR Third North American symposium on skeletal complications of malignancy. Cancer 97: 719-725, 2003.

Nagarajan R, Neglia J, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon M, Robison L. Education, employment, insurance and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Survey. Cancer 97(10), 2554-64, 2003.

Nagarajan R, Clohisy DR, Neglia J, et al: Function and quality of life of survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Study. Submitted 2003.

Clohisy DR:Metastatic bone disease: future directions. Clinical Orthopaedics and Related Research, Supplement: Metastases. Number 415, pp 1-5, 2003.

Ramnaraine ML, Pan W, Goblirsch M, Lynch C, Lewis V, Orchard P, Mantyh PW, Clohisy DR: Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Research, accepted for publication, June 2003.

Goblirsch M, Mathews W, Lynch C, Alaei P, Gerbi BJ, Mantyh PW, Clohisy DR: Radiation treatment decreases bone cancer pain, osteolysis, and tumor size. Submitted 2003.

Skubitz KM, Cheng EY, Clohisy DR, Thompson RC, Skubitz AP: Differential gene expression in liposarcoma, lipoma, and adipose tissue. Submitted 2003.

Book Chapters
Clohisy DR, "Pathophysiology of Metastatic Skeletal Disease", chapter in Orthopaedics, edited by Fitzgerald, Kaufer, Malkani, published by Mosby, 1078-1079, 2002.

Clohisy DR, Temple T: "Musculoskeletal Tumors", chapter in Orthopaedic Knowledge Update 7, edited by Kenneth Koval, published by AAOS, Rosemont IL, 155-182, 2002.

Clohisy DR: "Tumor osteolysis and skeletal pain", chapter in Molecular Biology in Orthopaedics. Edited by Randy N. Rosier and Chrisopher Evans, published by AAOS, Rosemont IL, 121-132, 2003.