University of Minnesota Children’s Hospital, Fairview Position(s)
Pediatric Blood and Marrow Transplant Physician

Other Related Positions Currently Held
Assistant Professor, Division of Hematology-Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota

Board Certifications
Pediatrics
Hematology/Oncology

Sees Patients At
-University of Minnesota Children’s Hospital, Fairview
-Blood and Marrow Transplant Clinic (Minneapolis)

Clinical Interests
Anemia
Antiphospholipid Syndrome
Antithrombin 3 Deficiency
Aplastic Anemia
Bleeding Disorders
Blood and Marrow Transplantation
Blood Cancer
Bone Cancer
Brain Tumor
Clotting Disorders
Colon Cancer
Colon Polyps
DVT
Ewings Sarcoma
Factor V Leiden
Gene Therapy for Correction of Genetic Diseases
Hemophilia
Hodgkins Disease
Hurler Syndrome
Kidney Cancer
Laryngeal Cancer
Leukemia
Liver Cancer
Lung Cancer
Lymphoma
Melanoma
Oral Cancer
Protein C and S Deficiency
Pulmonary Embolism
Testicular Cancer
Thrombosis
Thyroid Cancer
Transplantation for Metabolic Disorders
Transplantation Immunology
Von Willebrand Disease

Education
Medical School
Charles University, Prague, Czech Republic

Site of Residency
University of Minnesota (Pediatrics)

Site of Fellowship
University of Minnesota (Hematology/Oncology and Bone Marrow Transplantation)

Awards and Honors
National Cancer Institute Award (1995)
Boehringer Ingelheim Pharmaceuticals, Inc. Post-Doctoral Fellowship of the Amy Strelzer Manasevit Scholars Program (2002)
Masonic Dietz Family Award (2003)
Margaret Kendrick Hostetter MD Award for Research in Pediatric Subspeciality Training (1st place Fellow Research Symposium) (2003)
American Society of Clinical Oncology Young Investigator Award (2003)
NIH/NICHD Child Health Research Scholar (2003-2005)
University Pediatrics Foundation Scholar (2005)
Best Doctors in America®, 2007-2008

Research Interest(s)
Sleeping Beauty Transposons - Gene Therapy
Multipotent Adult Progenitor Cells (MAPC) and Mesenchymal Stem Cells (MSC) - Cellular Therapy
Mucopolysaccharidosis Type I (Hurler Syndrome) - Novel Therapies

Selected Recent Publications
Tolar J, O'shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Related Articles  Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood. 2006 Jan 12; [Epub ahead of print]

Tolar J, Osborn M, Bell S, McElmurry R, Xia L, Riddle M, Panoskaltsis-Mortari A, Jiang Y, McIvor R, Contag C, Yant S, Kay M, Verfaillie C, Blazar B. Real time in vivo imaging of stem cells following transgenesis by transposition. Molecular Therapy, 2005.

Tolar J, Bostrom B, Lee M, Sather, H. Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922. Pediatric Blood & Cancer 44:1-5, 2005.

Tolar J, Orchard P. Molecular etiology of human osteopetrosis. N Eng J Med 351(27):2839-49, 2004.

Gamberger D, Lavrac N, Zelezny F, Tolar J. Induction of comprehensible models of gene expression datasets by subgroup discovery methodology. Aug 37(4):269-84, 2004.

Tolar J, Tope W, Neglia JP. Leukotriene receptor inhibition for the treatment of systemic mastocytosis. Letter. N Engl J Med 350:735-6, 2004.

Wagner JE, Tolar J, Levran O, Scholl T, Deffenbaugh A, Satagopan J, Ben-Porat L, Mah K, Dev Batish S, Kutler DI, MacMillan ML, Hanenberg H, Auerbach AD. Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia and Fanconi anemia. Blood 103: 3226 - 3229, 2004.

Tolar J, Neglia JP. Transplacental and other routes of cancer transmission between individuals: a review of the literature. J Pediatr Hematol Oncol 25:430-4, 2003.

Tolar J, Coad JE, Neglia JP. Transplacental transfer of maternal small cell carcinoma of the lung. N Engl J Med 346:1501-2, 2002.