University of Minnesota Children’s Hospital, Fairview Position(s)
Pediatric Blood and Marrow Transplant Physician

Other Related Positions Currently Held
Assistant Professor, Division of Hematology-Oncology and Blood and Marrow Transplantation, University of Minnesota

Clinical Medical Director, Pediatric BMT Program, University of Minnesota

Co-Director, Fanconi Anemia Comprehensive Care Clinic, University of Minnesota

Medical Director, Unrelated Donor Program, University of Minnesota

Board Certifications
Pediatrics 
Pediatric Hematology/Oncology

Sees Patients At
-University of Minnesota Children’s Hospital, Fairview
-Blood and Marrow Transplant Clinic (Minneapolis)
-Masonic Cancer Clinic (Minneapolis)

Clinical Interests
Anemia
Antiphospholipid Syndrome
Antithrombin 3 Deficiency
Bleeding Disorders
Blood Cancer
Blood and Marrow Transplantation
Bone Cancer
Brain Tumor
Chemotherapy
Clotting Disorders
Colon Cancer
Colon Polyps
Deep Vein Thrombosis
Ewings Sarcoma
Factor V Leiden
Fanconi amemia
Hemophilia
Hodgkins Disease
Hurler Syndrome
Juvenile Myelomonocytic Leukemia
Kidney Cancer
Laryngeal Cancer
Leukemia
Liver Cancer
Lung Cancer
Lymphoma
Melanoma
Oral Cancer
Protein C and S Deficiency
Pulmonary Embolism
Testicular Cancer
Thrombosis
Thyroid Cancer
Von Willebrand Disease

Education
Medical School
University of Toronto

Site of Internship
The Hospital for Sick Children, Toronto, Canada

Site of Residency
The Hospital for Sick Children, Toronto, Canada (Pediatrics)

Site of Fellowship
University of Toronto School of Medicine (Hematology-Oncology);
University of Minnesota (Blood and Marrow Transplant)

Awards and Honors
1997, Cooley's Anemia Fellowship, Boston, Massachusetts
2000, Irvine McQuarrie Research Scholar, University of Minnesota
Best Doctors in America®, 2007-2008

Research Interest(s)
Development and Implementation of Novel Strategies for Preventing the Immunologic Complications of Allogeneic Hematopoietic Stem Cell Transplantation
Acute Graft-Versus-Host Disease
  - T regulatory cells to prevent GVHD
  - Novel pharmacologic agents/ regimens
Fanconi anemia
  - Novel preparative therapies
  - Gene therapy - multipotent adult stem cell
  - Mechanisms to speed immune recovery and reduce infection after transplantation
Juvenile Myelomonocytic Leukemia
 - Novel phase I agents
 - Novel preparative therapies

Selected Recent Publications
Tan PL, Wagner JE, Auerbach AD, DeFor TE, Slungaard A, and MacMillan ML. Successful engraftmment without radiation after fludarabine-based regimen in Fanconi Anemia patients undergoing genotypically identical donor hematopoietic cell transplantation. Pediatric Blood and Cancer.  46:630-636, 2006.

Barker J, Hough RE, van Burik J, DeFor T, MacMillan ML, O’Brien MR, Wagner JE.  Serious Infections After Unrelated Donor Transplantation in 136 Children: Impact of Stem Cell Source.  Biol  Blood Marrow Tranplant. 11:362-70 (005.

MacMillan ML and Wagner JE. Hematopoietic cell transplantation on congenital bone marrow failure. Current Opinions in Oncology, 17:106-113, 2005.

Pinto-Cardoso SM, DeFor TE, Tilley LA, Bidwell JL, Weisdorf DJ and MacMillan ML. Patient interleukin-18 GCG haplotype associates with improved survival and decreased transplant-related mortality after unrelated-donor bone marrow transplantation. British Journal of Hematology, 126:704-710, 2004.

MacMillan ML, Radloff G.A, DeFor TE, Weisdorf DJ and Davies SM. IL-1 genotype and outcome of unrelated donor bone marrow transplantation. British Journal of Hematology, 121:597-604,2003.

Kumar AR, Wagner JE, Auerbach AE, Coad JE, Dietz CA, Schwarzenberg SJ and MacMillan ML. Fatal intrahepatic hemorrhage due to androgen-related hepatic adenomas after hematopoietic cell transplantation. Journal of Pediatric Hematology/Oncology, 26(1):16-18, 2004.

MacMillan ML, Radloff GA, DeFor TE, Weisdorf DJ and Davies S.M. High producer IL-2 genotype increases risk for acute GVHD after unrelated donor bone marrow transplantation. Transplantation, 76:1758-1762, 2003.

Wagner JE, MacMillan ML, Auerbach AD.  Hematopoietic cell transplantation for Fanconi Anemia.  In: Blue KG, Forman SJ, Appelbaum FR, eds. Thomas, Hematopoietic Cell Transplantation.  Blackwell Publishing Ltd, Oxford, 2003.

MacMillan ML, Weisdorf DJ, Wagner JE, DeFor TE, Burns LJ, Ramsay NKC, Davies SM, Blazar BR. Response of 443 patients to steroids as primary therapy for acute graft-versus-host-disease: Comparison of grading systems. Biology of Blood and Marrow Transplantation, 8:387-394,2002.

MacMillan ML, Goodman JL, Defor TE and Weisdorf DJ. Fluconazole to Prevent Fungal Infections in Bone Marrow Transplantation Patients: Randomized Comparative Trial of High Versus Reduced Dose and Determination of the Value of Maintenance Therapy. American Journal of Medicine, 112:369-379,2002.

MacMillan ML, Weisdorf DJ, Davies SM, DeFor TE, Burns LJ, Ramsay NK, Wagner JE and Blazar BR. Early Antithymocyte Globulin Therapy Improves Survival in Patients With Steroid-Resistant Acute Graft-Versus-Host Disease. Biology of Blood and Marrow Transplantation, 8:40-46,2002.

MacMillan ML, Auerbach AD, Davies SM, DeFor TE, Gillio A, Giller R, Harris R, Cairo M, Dusenberry K, Hirsch B, Ramsay NKC, Weisdorf DJ and Wagner JE. Hematopoietic cell transplantation in patients with Fanconi Anemia using non-genotypically identical donors: Results of a TBI dose escalation trial. British Journal of Hematology 108:1-10, 2000.