University of Minnesota Children’s Hospital, Fairview Position(s)
Pediatric Hematologist Oncologist
Other Related Positions Currently Held
Assistant Professor, Department of Pediatrics, University of Minnesota
Assistant Professor, Cancer Center, University of Minnesota
Sees Patients At
-University of Minnesota Children’s Hospital, Fairview
-Masonic Cancer Clinic (Minneapolis)
Clinical Interests
Anemia
Antiphospholipid Syndrome
Antithrombin 3 Deficiency
Bleeding Disorders
Blood Cancer
Bone Cancer
Brain Tumor
Chemotherapy
Clotting Disorders
Colon Cancer
Colon Polyps
Developmental Therapeutics
DVT
Ewings Sarcoma
Factor V Leiden
Hemophilia
Hodgkins Disease
Hurler Syndrome
Kidney Cancer
Laryngeal Cancer
Leukemia
Liver Cancer
Lung Cancer
Lymphoma
Melanoma
Oral Cancer
Protein C and S Deficiency
Pulmonary Embolism
Sarcomas
Testicular Cancer
Thrombosis
Thyroid Cancer
Von Willebrand Disease
Education
Medical School
MacMaster University, Hamilton, Ontario
Site of Residency
University of Western Ontario (Pediatrics)
Site of Fellowship
University of Minnesota (Pediatric Hematology/Oncology and Bone Marrow Transplantation)
Awards and Honors
Research Training Fellowship, The Research Institute of The Hospital for Sick Children, 1989-1990
Farquharson Fund - MRC Research Scholarship, 1991-1992
Chief Resident, Pediatrics, University of Western Ontario, 1995-1996
PAIRO Residency Teaching Award, 1995-1996
Chief Fellow, Pediatric Hematology/Oncology,University of Minnesota, 1998-2000
Young Investigator Award, American Society of Clinical Oncology, 1999
Young Investigator Award, Children's Oncology Group (formerly known as Children's Cancer Group), 2000
Young Investigator Award, Children's Oncology Group, 2001
Translational Research Award, Children's Oncology Group, 2002
University Pediatrics Foundation Scholar Award, University of Minnesota, 2003
Lehman/Children's Cancer Research Fund, Endowed Chair in Pediatric Cancer, 2004
Alexander Charles Jundt Research Award, 2005
Best Doctors in America®, 2007-2008
Research Interest(s)
Immunotherapy for Rhabdomyosarcoma:
Novel Agents Used in Combination with Chemotherapy and/or Surgery
Understanding the Immune Mechanisms Involved
New Agents for AML:
Evaluating Many New Immunomodulatory Drugs in an AML Model
Developing New Clinical Trials Using Come of These Agents
Selected Recent Publications
Smith AR, Repka TL, Weigel BJ, Aprepitant for the control of chemotherapy induced nausea and vomiting in adolescents. Pediatr Blood Cancer 45(6): 857-860;2005.
Nagarajan R, Clohisy D, Weigel B. New paradigms for therapy for osteosarcoma. Curr Oncol Rep 7(6):410-414;2005.
Fraser CJ, Weigel BJ, Perentesis JP, DeFor TE, Baker KS, Verneris MR. Autologous stem cell transplantation for high risk Ewing’s sarcoma and other pediatric solid tumors. Bone Marrow Transplant 37(2):175-81;2006.
Weigel BJ, Breitfeld PP, Hawkins D, Crist WM, Baker KS. The role of myeloablative chemotherapy with stem cell rescue in the treatment of metastatic or recurrent rhabdomyosarcoma. J Pediatr Hematol Oncol 23:272-276, 2001.
Pawlowska AB, Hashino S, McKenna H, Weigel BJ, Taylor PA, Blazar BR. In vitro tumor pulsed or in vivo Flt3 ligand generated dendritic cells (DCs) provide protection against acute myelogenous leukemia (AML) in non-transplanted or syngeneic bone marrow transplanted mice. Blood 97:1474-1482, 2001.
Weigel BJ, Nath N, Taylor PA, Panoskaltsis-Mortari A, Chen W, Krieg AM, Brasel K, Blazar BR. Comparative analysis of murine marrow derived dendritic cells generated by FLT3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of anti-leukemia responses. Blood 100:4169-4176, 2002.
Harmala LAE, Inguilli EG, Curtsinger JM, Lucido MM, Schmidt CS, Weigel BJ, Blazar BR, Mescher MF, Pennell CA. The adjuvant effects of mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo. J Immunol 169:5622-5629, 2002.
Weigel BJ, Rodeberg DA, Krieg AM, Blazar BR. CpG Oligodeoxynucleotides Potentiate the Anti-tumor Effects of Chemotherapy or Tumor Resection in an Orthotopic Murine Model of Rhabdomyosarcoma. Clin Cancer Research 9:3105-3114, 2003.
Nagarajan R, Weigel BJ, Thompson RC, Perentesis JP. Osteosarcoma in the first decade of life. Med Pediatr Oncol 41:480-3, 2003.
Sauer MG, Ericson ME, Weigel BJ, Herron MJ, Panoskaltsis-Mortari A, Kren BT, Levine BL, Serody JS, June CH, Taylor PA, Blazar BR. A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytoxic T cells (CTLs) Cancer Res. 2004 64: 3914-3921.
